Yeah, it is known as the 'Great Dying'. Since you mentioned the Permian Extinction you could have also included the four other mass extinction events that happened long before humans were a thing. I am talking about the:

. Ordovician-Silurian Mass Extinction

. Late Devonian Mass Extinction

. Triassic-Jurassic Mass Extinction

. Cretaceous-Paleogene Mass Extinction